The Trump administration is set to impose sweeping tariffs on imports from Canada, Mexico, and China starting Saturday, a move that could strain relations with three of the U.S.’s top trading partners while driving up prices on essential goods like gasoline and groceries.

Under the new policy, the administration will enforce a 25% tariff on all imports from Canada and Mexico and a 10% tariff on goods from China.

Hours before the tariffs were set to take effect, leaders from Canada and Mexico vowed to retaliate, raising fears of a potential trade war that could further disrupt global supply chains.

Experts warn that these tariffs will likely lead to price hikes on a broad range of consumer products, including avocados, tequila, and auto parts, as importers typically pass along the costs to consumers. However, some businesses within the supply chain may absorb part of the cost, making the full impact on prices uncertain.

At a White House briefing on Friday, Press Secretary Karoline Leavitt justified the tariffs by accusing the three targeted nations of facilitating the manufacture and transport of illicit drugs into the U.S.

“Canada, Mexico, and China have all enabled illegal drugs to pour into America,” Leavitt said, echoing previous remarks by President Donald Trump, who proposed the tariffs weeks after his re-election victory.

Leavitt defended the administration’s stance, calling the move “promises made and promises kept” as Trump follows through on campaign pledges to take a hardline approach on trade and national security.