Iran’s Supreme Leader, Ayatollah Ali Khamenei, has declared that the country’s longstanding dispute with the United States is beyond resolution, asserting that Tehran will never yield to American pressure. His remarks, broadcast on state media Sunday, come amid a renewed diplomatic push by European nations to salvage nuclear talks.

“The Americans want Iran to surrender. The Iranian people will resist with full strength against such misguided expectations,” Khamenei stated, rejecting appeals for direct talks with Washington. “Some advise us to avoid slogans and seek engagement, but they fail to see the reality. This issue is unsolvable,” he added.

Tehran suspended talks with the United States following coordinated U.S. and Israeli airstrikes on Iranian nuclear sites during a 12-day conflict in June. Despite those tensions, Iran and European powers announced last week a tentative agreement to resume discussions focused on curbing Iran’s uranium enrichment program.

France, the United Kingdom, and Germany have warned they may trigger the United Nations “snapback” sanctions mechanism if Iran fails to engage seriously. Western governments, along with the U.S., accuse Iran of pursuing nuclear weapons—a claim Tehran denies, insisting its nuclear efforts are for civilian energy use.

Khamenei’s uncompromising rhetoric highlights the deepening divide between Iran and the West, casting doubt on the prospects for a diplomatic breakthrough in the near term.