At least 30 people have been confirmed dead, with many more missing, in North Carolina’s Buncombe County following catastrophic flooding caused by Hurricane Helene. The full extent of the storm’s destruction became clearer on Sunday, with Buncombe County, home to the mountain city of Asheville, identified as the worst-hit region.

“We are facing biblical devastation,” said Ryan Cole, a county emergency official. “This is the most significant natural disaster any of us have ever witnessed.”

Nationwide, at least 105 people have lost their lives since Helene made landfall in Florida on Thursday, according to CBS, and the death toll is expected to rise as rescue teams access more isolated areas.

Helene, which began as a powerful hurricane, wreaked havoc as it moved from Florida through Georgia, the Carolinas, and Tennessee. While it downgraded to a tropical storm, the majority of fatalities occurred in North and South Carolina.

In Buncombe County alone, officials reported 30 fatalities by Sunday evening, with around 1,000 people still unaccounted for. Rescue efforts have been hindered by widespread power outages, downed trees, and blocked roads.

As residents returned to assess the damage, many found their homes completely destroyed. North Carolina Governor Roy Cooper described the storm as having caused “catastrophic devastation of historic proportions.”

The American Red Cross has opened over 140 shelters across the southeastern states for those displaced by the storm, with more than 2,000 people seeking refuge as of Sunday.